The Tubulin Code; see reference for complete report. “>> ABSTRACT Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure, microtubules fulfill a large diversity of functions. A regulatory mechanism to control the specialization of the microtubule cytoskeleton is the ‘tubulin code’, which is […]

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers; see reference for complete report. “>> Question What is the association between plasma phospho-tau and total-tau levels and traumatic brain injury presence, severity, type of pathoanatomic lesions, and patient outcome? Findings In a cohort study, plasma […]

Genetics Quickview in Amyotrophic lateral sclerosis (ALS) and Frontotemporal Dementia (FTD), Alzheimer’s Disease, Dystonia, other Brain Misfolding and Aggregation Proteinopathies: • Now >100 genes are known to contribute to ALS/FTD, with a few major contributors that are reviewed below • ALS, is a sporadic disease with genetic and environmental contributions, • Tau Protein, was the […]